550 5.1.0 address rejected means the receiving server refused your message over an address, and often not the one you typed. On Microsoft 365 the causes are the recipient's block list, a stale Outlook suggestion, or an SPF error on your own domain. In the code, the 1 marks the addressing group and the final 0 says only that some address caused it.
How to read the result
Paste the whole bounce, including the part headed "Diagnostic information for administrators". That part sorts the causes:
Only "Address Rejected", nothing about SPF. Start with the recipient's block list, or a stale suggestion in your own address book.
"SPF Permanent Error". Your domain's SPF record is broken. The recipient's address is fine, and resending changes nothing until the record is fixed.
"550 #5.1.0 Address rejected", with a hash. The same code, in another mail service's format.
How to fix 550 5.1.0
Others at the same domain get your mail. The recipient probably blocks you. Ask them by phone or in person.
You picked the address from Outlook's suggestions. Delete the suggestion and type the address in full. Microsoft's fix page for 550 5.1.0 explains how a mailbox move breaks the cached entry.
SPF permanent error. Under the SPF standard, the record could not be read: a syntax error, two SPF records on one domain, or too many DNS lookups. Fix the record you have before you add another service to it.
Colleagues bounce at that domain too. The recipient's server blocks your organization, and your admin takes it up with theirs.
What to do next
If the recipient blocked you on purpose, respect it. In Oneprofile, adding the address to your do-not-contact list stops every sequence email and LinkedIn step to that person before it sends.
For the other causes, fix the entry or the record, then send the same message again.
